CBD and Other Cannabinoids

CBD and Other Cannabinoids


Medical cannabis has been used for a variety of conditions. Cannabinoids, the active ingredients  contained within the cannabis plant, work on specific neuroendocrine receptors within the body  called the endocannabinoid system. Although the cannabis plant contains about 113 different  cannabinoids,  most  research  has  been  performed  on  tetrahydrocannabinol‐9 (THC)  and  cannabidiol (CBD).  THC is the component of cannabis that has psychoactive properties and causes the “high”  experienced by marijuana users. THC is used in the medical setting for pain, difficulty sleeping, appetite stimulation, and for nausea and vomiting.

Medical Conditions that may be Improved with CBD

The  biochemical properties of CBD may produce beneficial effects for patients with a variety of  diseases.  Most  commonly,  CBD  is  used  in  the  clinical  setting  for  patients  with  chronic  pain,  depression and anxiety. Below is a list of somer conditions that have been treated with CBD

  • Chronic Pain
  • Depression
  • Anxiety
  • Crohn’s Disease 
  • Rheumatoid Arthritis
  • Insomnia
  • Epilepsy
  • Nausea/ Vomiting
  • Multiple Sclerosis 
  • Essential Tremors


Bocaliner and Absorption of CBD

One challenging aspect of using CBD  as a medication is that it is poorly absorbed and readily broken down (metabolized) by the body.  For example, when CBD is taken orally, only about 5% of the active ingredient is absorbed. This  means that if a patient consumes 100 mg of CBD as an edible or capsule, only 5 mg of CBD gets  into the body to perform a medical function. To improve this situation, CBD is mixed in oil such as coconut oil, grape seed or hemp oil and is administered with a  medicine dropper under the tongue.  It has been estimated that between 13 and 19% percent of  active CBD is absorbed when CBD oil is administered sublingually (under the tongue). At present,  the sublingual dosing of CBD oil is the most used form of CBD. Patients are instructed to try to keep the CBD oil under the tongue for at  least 60 seconds. If they can keep the CBD oil under their tongue longer,  better  absorption  of  the  CBD  oil  takes place  with better  effects.  

Bocaliner increases the sublingual absorption of substances. Our studies show that Bocaliner increases the time that sublingually administered CBD stays in the mouth. In addition, when Bocaliner is used, the concentration of CBD that stays under the tongue is higher. This should lead to a better effect from sublingual CBD. The graph below shows how Bocaliner effects the absorption of sublingual CBD. In this study, the mixture was placed under the tongue using a medicine dropper. This study shows that the CBD stayed for a longer time, at a higher concentration, inside of the mouth.